Sec7p

Sec7p is a protein found in the yeast Saccharomyces cerevisiae. It is a component of the Sec61p translocon, a complex that forms a channel through the endoplasmic reticulum membrane. This channel is essential for the translocation of proteins from the cytoplasm into the endoplasmic reticulum lumen or across the ER membrane. Sec7p is a transmembrane protein and is believed to play a role in the gating mechanism of the translocon, regulating the passage of polypeptides.

The Sec61p translocon is composed of three core subunits: Sec61p, Sec62p, and Sec7p. These subunits work together to facilitate protein insertion into the ER membrane and translocation into the ER lumen. Sec7p's precise function within this complex is still an area of active research, but studies suggest it is crucial for the efficient and regulated movement of proteins. Mutations in the gene encoding Sec7p can lead to defects in protein translocation, impacting various cellular processes. Understanding Sec7p's role is vital for comprehending protein biogenesis and the proper functioning of the endoplasmic reticulum.