Rab27arelated
Rab27a is a small GTPase that plays a crucial role in intracellular vesicle trafficking, particularly in the regulated secretion of various cellular products. It is a member of the Rab family of proteins, which are known for their involvement in vesicle budding, movement, and fusion. Rab27a is specifically associated with the transport and docking of secretory vesicles to the plasma membrane.
This protein functions by interacting with a range of effector proteins, which in turn recruit other machinery
Mutations or deficiencies in Rab27a are linked to several human diseases. Griscelli syndrome type 2 (GS2) is