PEX19independent
PEX19-independent pathways refer to cellular mechanisms that facilitate the biogenesis and maintenance of peroxisomes, membrane-bound organelles involved in lipid metabolism and reactive oxygen species detoxification, without relying on the PEX19 protein. While the majority of peroxisomal membrane proteins are imported via the PEX19-dependent pathway—where PEX19 acts as a chaperone to deliver newly synthesized proteins to the peroxisomal membrane—some proteins can be incorporated independently of this process.
The PEX19-independent pathway has been observed in certain organisms, including yeast and mammals, and appears to
Research suggests that this pathway may play a role in the incorporation of specific membrane proteins, such
Studies on PEX19-independent pathways have implications for understanding peroxisomal disorders, particularly those caused by mutations in