OATP4C1

OATP4C1, also known as SLCO4C1, is a protein that functions as an organic anion transporting polypeptide. It is encoded by the SLCO4C1 gene and belongs to the solute carrier organic anion transporter family. This protein is primarily expressed in the kidney, specifically in the proximal tubules, and also in the liver. Its main role is to facilitate the uptake and efflux of various organic anions across cell membranes.

The physiological function of OATP4C1 is not fully elucidated, but research suggests it plays a role in the renal excretion of certain endogenous and exogenous compounds. It is believed to be involved in the transport of bile acids, hormones, and potentially drugs. Its expression levels can be influenced by various physiological conditions and it may contribute to drug metabolism and elimination. Dysregulation or mutations in the OATP4C1 gene have been implicated in certain kidney diseases, though further research is ongoing to understand these associations more clearly. Its precise substrate specificity and transport mechanisms are areas of active investigation within the scientific community.