Neutrophilenverschiebung
Neutrophil-derived vesicles (NDVs) are membrane-bound particles released by neutrophils during activation, degranulation, or apoptosis. They are a heterogeneous population that can range from about 50 to 1000 nanometers in diameter and carry neutrophil-derived proteins such as myeloperoxidase, elastase, and lactoferrin, as well as lipids and nucleic acids. The exact composition of NDVs depends on the stimulus, the neutrophil’s activation state, and the microenvironment.
Formation of neutrophil-derived vesicles occurs in response to proinflammatory signals such as C5a, TNF-α, IL-8, and
Functions attributed to NDVs include modulation of recipient cells within the vasculature and immune system. They
Clinical relevance is an area of ongoing study. NDVs are investigated as potential biomarkers of inflammatory