NeutrophilenElastase

NeutrophilenElastase, also known as human leukocyte elastase or M27, is a serine protease found in the azurophilic granules of neutrophils. Neutrophils are a type of white blood cell that plays a crucial role in the innate immune system, particularly in combating bacterial and fungal infections. NeutrophilenElastase is released into the extracellular environment during neutrophil activation, such as in response to inflammation or tissue damage. Its primary function is to degrade foreign pathogens. However, it also possesses the ability to break down host proteins, including elastin, a key component of connective tissues like skin, lungs, and blood vessels. This dual function highlights its importance in defense but also its potential to contribute to tissue damage if its activity is not properly regulated. Dysregulation or excessive release of NeutrophilenElastase has been implicated in the pathogenesis of various inflammatory and degenerative diseases, including chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, and atherosclerosis. The enzyme's activity is normally controlled by endogenous inhibitors, such as alpha-1 antitrypsin, which neutralize its proteolytic capacity.