NaK2Clkotransporter
NaK2Cl cotransporter is a membrane protein responsible for the active transport of sodium (Na+), potassium (K+), and chloride (Cl-) ions across cellular membranes. This transporter plays a critical role in maintaining ion balance, cell volume regulation, and electrical stability in various tissues, particularly in the kidney, brain, and other epithelia.
The NaK2Cl cotransporter belongs to the solute carrier (SLC) family, specifically the SLC12 gene family, with
This transporter operates via secondary active transport, utilizing the electrochemical gradient of sodium generated by the
The functionality of NaK2Cl cotransporters is regulated through phosphorylation and other post-translational modifications. Pharmacological agents such
Mutations or dysregulation of these transporters can lead to clinical conditions such as Bartter syndrome, characterized