NOX1

NOX1, also known as NADPH oxidase 1, is a protein-coding gene. It is a member of the NADPH oxidase family, enzymes that generate reactive oxygen species (ROS). Specifically, NOX1 produces superoxide radicals. These ROS play a role in various cellular processes, including signaling and defense. NOX1 is primarily expressed in the colon and is involved in the regulation of intestinal epithelial cell function. It is thought to contribute to epithelial barrier integrity and potentially play a role in inflammation. Dysregulation of NOX1 activity has been implicated in several gastrointestinal diseases, including inflammatory bowel disease and colorectal cancer. The enzyme requires accessory proteins for its activation, such as NOXO1 (also known as p47phox) and CYBA (also known as p22phox). Research into NOX1 continues to explore its precise functions and potential as a therapeutic target.