MichaelisMeneten

MichaelisMenten is a mathematical model used to describe the rate of an enzyme-catalyzed reaction. It was developed by Leonor Michaelis and Maud Menten in 1913. The model assumes that the reaction rate is proportional to the concentration of the substrate and the enzyme, and that the enzyme-substrate complex is in a rapid equilibrium with the products. The Michaelis-Menten equation is given by:

V = (Vmax * [S]) / (Km + [S])

where V is the reaction rate, Vmax is the maximum reaction rate, [S] is the substrate concentration, and Km is the Michaelis constant, which is the substrate concentration at which the reaction rate is half of Vmax. The Michaelis-Menten model has been widely used in biochemistry and pharmacology to study enzyme kinetics and drug action. However, it has limitations, such as assuming that the enzyme is homogeneous and that the reaction is irreversible. Despite these limitations, the Michaelis-Menten model remains a fundamental concept in the study of enzyme-catalyzed reactions.