Metallokarboksüpeptidaases

Metallocarboxypeptidases are a class of enzymes belonging to the carboxypeptidase family. These enzymes are characterized by their requirement for a metal ion, typically zinc, as a cofactor for their catalytic activity. Metallocarboxypeptidases function by cleaving amino acids from the carboxyl terminus of peptide chains. This enzymatic activity is crucial in various biological processes, including protein degradation, peptide hormone processing, and digestive pathways. They are found in a wide range of organisms, from bacteria to mammals. The specific metal ion and the surrounding amino acid residues in the enzyme's active site determine its substrate specificity and catalytic efficiency. Dysfunction or altered activity of metallocarboxypeptidases can be associated with certain diseases, highlighting their importance in maintaining physiological homeostasis. Research into metallocarboxypeptidases continues to explore their diverse roles and potential as therapeutic targets.