Koncentrationsområde

Koncentrationsområde is a term used in analytical chemistry and related fields to describe the interval of concentrations over which a measurement method, assay, or instrument provides reliable and interpretable results. It encompasses the range within which responses are proportional to concentration (linearity) and the method meets predefined accuracy and precision criteria. The concept is closely linked to the calibration range and the dynamic range of the analytical procedure.

Key aspects include linearity, accuracy, and precision, which are established during method validation. The concentration range is typically defined by the lower and upper limits of quantification (LLOQ and ULOQ) or by detection limits and the point where the response begins to saturate or become non-linear. A well-defined koncentrationsområde ensures that quantitative results are trustworthy and comparable across analyses and laboratories.

Determination of the koncentrationsområde involves preparing calibration standards spanning the expected concentrations, constructing a calibration curve, and evaluating criteria such as regression quality, back-calculated accuracy, and within-run precision. In practice, samples outside this range may require dilution or concentration steps to bring them into the valid range.

Applications span clinical chemistry, pharmacokinetics, environmental monitoring, and any field relying on quantitative measurements. The term emphasizes the importance of operating within validated limits to ensure data quality, reproducibility, and meaningful interpretation.