INPP5A

INPP5A, also known as Inositol Polyphosphate-5-Phosphatase 5-alpha, is an enzyme encoded by the INPP5A gene. This gene is located on chromosome 16. The INPP5A protein is a member of the inositol polyphosphate phosphatase family and plays a crucial role in cellular signaling pathways. Specifically, it dephosphorylates inositol 1,4,5-trisphosphate (IP3) and inositol 1,3,4,5-tetrakisphosphate (IP4), which are important second messengers involved in calcium mobilization and various cellular processes.

The activity of INPP5A is regulated by various cellular mechanisms, and its dysregulation has been linked to several diseases. Research suggests that INPP5A is involved in cell growth, proliferation, and differentiation. Its role in modulating intracellular calcium levels makes it a key player in signal transduction pathways that control a wide range of cellular functions. Aberrant expression or activity of INPP5A has been implicated in the pathogenesis of certain cancers, developmental disorders, and neurological conditions. Further research is ongoing to fully elucidate the complex roles of INPP5A in health and disease and to explore its potential as a therapeutic target.