Bfibrinopeptideistä

Bfibrinopeptideistä, also known as fibrinopeptides, are small peptides that are cleaved from fibrinogen to initiate the formation of a fibrin clot. Fibrinogen is a soluble protein circulating in the blood plasma. When tissue injury or other stimuli trigger the coagulation cascade, an enzyme called thrombin is activated. Thrombin then acts on fibrinogen, cleaving off the Bfibrinopeptide A and Bfibrinopeptide B molecules. This cleavage exposes polymerization sites on the remaining fibrin molecule. These exposed sites allow fibrin monomers to spontaneously aggregate and form long, insoluble fibrin strands. These strands then assemble into a mesh-like network that traps blood cells and platelets, forming a stable blood clot. Bfibrinopeptide A is released first, followed by Bfibrinopeptide B, although the order can vary depending on the specific activation pathway. The release of these peptides is a critical step in hemostasis, the process of stopping bleeding. Once released into the circulation, Bfibrinopeptides are rapidly cleared and do not typically accumulate in healthy individuals. Their presence in elevated levels can be indicative of increased thrombotic activity.