BPTF
BPTF, short for Bromodomain PHD finger Transcription Factor, is a protein encoded by the human BPTF gene. It is the largest subunit of the NURF chromatin remodeling complex, which regulates access to DNA by remodeling nucleosomes. BPTF contains a bromodomain and a plant homeodomain (PHD) finger that recognize histone marks, helping to direct the remodeling activity to regions of active chromatin.
Function: As part of NURF, BPTF participates in ATP-dependent repositioning of nucleosomes, enabling transcription, DNA replication,
Biological role: BPTF is broadly expressed and contributes to development and differentiation. Mouse models show that
Clinical relevance: Alterations and changes in expression of BPTF have been linked to cancer and developmental
See also: NURF chromatin remodeling complex, ISWI family, bromodomain, PHD finger.