Autoantigénekre

Autoantigénekre refers to the self-antigens that are recognized by the immune system. Normally, the immune system is trained to distinguish between self and non-self molecules, preventing attacks on the body's own tissues. Autoantigens are substances produced by the body's own cells that are typically present during fetal development or in specific cells. In healthy individuals, these antigens do not provoke an immune response due to a process called immune tolerance.

However, in certain autoimmune diseases, this tolerance breaks down. The immune system mistakenly identifies these autoantigens as foreign invaders and mounts an attack against them. This can lead to chronic inflammation and damage to various organs and tissues. The specific autoantigens involved vary depending on the autoimmune disease. For example, in type 1 diabetes, autoantigens on pancreatic beta cells are targeted, while in rheumatoid arthritis, autoantigens in the joints are attacked.

Understanding autoantigens is crucial for diagnosing and treating autoimmune disorders. Identifying the specific autoantigens involved in a particular disease can help in developing targeted therapies, such as immunosuppressants or immunotherapies, aimed at restoring immune tolerance and preventing further damage. Research into autoantigens continues to be a key area in immunology, seeking to unravel the complex mechanisms behind autoimmunity and find effective ways to manage these conditions.