Ampoule

An ampoule (also spelled ampule) is a small, sealed container used to hold a sterile pharmaceutical solution or powder intended for single-dose administration. Most are made of glass and are designed to be opened by snapping off the neck; some plastic variants exist. The contents remain sterile until use, and the ampoule is sealed by fusing the neck during manufacture.

Opening and contents: The neck is designed to break at a predefined point. Opening requires breaking the neck, usually with an ampoule opener or sterile technique, and the contents are drawn into a syringe under aseptic conditions. Some ampoules contain lyophilised powders that must be reconstituted with a diluent before use. The product is intended for single-patient, single-use; any unused portion should be discarded to prevent contamination.

Applications and design: Ampoules are used for injectable medicines, vaccines, and some ophthalmic solutions, providing a hermetically sealed environment that protects contents from air and contaminants until use. They are not intended to be resealed after opening. Many ampoules include tamper-evident features to indicate modification or opening.

Storage and safety: Store according to the product label, protecting contents from excessive heat, light, and moisture when applicable. After opening, contents should be used promptly; contaminated or partially used ampoules should be discarded. Disposal should follow local regulations for broken glass and pharmaceutical waste, and broken ampoules should be handled with care to prevent injury.