Ametikoolides

Ametikoolides are a group of polyketide antibiotics produced by various species of Streptomyces. They are characterized by their unique chemical structure, which includes a 12-membered macrolide ring and a 14-membered diketopiperazine ring. Ametikoolides exhibit a wide range of biological activities, including antibacterial, antifungal, and antiviral properties. The most well-known member of this group is ametikacin, which has been studied for its potential use in the treatment of multidrug-resistant bacterial infections. Ametikoolides are typically isolated from soil samples and are produced through fermentation processes. Their complex structure and biological activities have made them a subject of interest for further research and development in the field of antibiotic discovery.