ADPribosilasyonu
ADPribosilasyonu is a fundamental post-translational modification that plays a crucial role in numerous cellular processes. This enzymatic process involves the transfer of one or more ADP-ribose units from NAD+ to a target protein. The modification can occur on various amino acid residues, including aspartate, glutamate, lysine, arginine, cysteine, and even to the C-terminus of proteins. The enzymes responsible for catalyzing ADPribosylation are known as ADP-ribosyltransferases (ARTs). These enzymes can add a single ADP-ribose moiety (mono-ADP-ribosylation) or multiple ADP-ribose units, forming long chains (poly-ADP-ribosylation).
The functions of ADPribosylation are diverse and context-dependent. Mono-ADP-ribosylation has been implicated in regulating protein-protein interactions,