ACSL3

ACSL3, or Acyl-CoA Synthetase Long Chain Family Member 3, is a protein-coding gene. This gene is part of the acyl-CoA synthetase family, which are enzymes responsible for activating fatty acids by converting them into acyl-CoA thioesters. This activation is a crucial initial step in various metabolic pathways, including fatty acid oxidation, lipid synthesis, and membrane trafficking.

The ACSL3 protein specifically plays a role in the elongation and desaturation of fatty acids. It is involved in the synthesis of very long-chain fatty acids (VLCFAs), which are important components of cellular membranes and are also involved in signaling pathways. Research suggests that ACSL3 is particularly important in the liver and brain. Its expression levels can vary depending on cellular conditions and metabolic state. Dysregulation of ACSL3 has been implicated in certain diseases, including some forms of cancer and neurological disorders, although its precise role in these conditions is still under investigation. Further research continues to elucidate the full spectrum of ACSL3 functions and its involvement in human health and disease.