4HydroxybenzoylCoA

4-Hydroxybenzoyl-CoA is a Coenzyme A (CoA) ester of 4-hydroxybenzoic acid. It is an intermediate in the benzoate degradation pathway, which is a metabolic pathway that breaks down benzoic acid and its derivatives in certain organisms.

In the benzoate degradation pathway, 4-hydroxybenzoyl-CoA is formed from the hydroxylation of benzoyl-CoA, a CoA ester of benzoyl-CoA. This step is catalyzed by the enzyme benzoyl-CoA 2,3-dioxygenase. 4-Hydroxybenzoyl-CoA is then converted into 3-hydroxybenzoyl-CoA through a dehydration reaction.

The further metabolism of 4-hydroxybenzoyl-CoA involves its conversion into 5-carboxybenzyl-CoA, which is then decarboxylated to form 4-hydroxybenzaldehyde. This aldehyde can be further converted into other metabolic intermediates.

4-Hydroxybenzoyl-CoA is an intermediate in the metabolism of several different compounds, including benzoic acid and its derivatives, which are widespread in the environment. The enzyme benzoyl-CoA 2,3-dioxygenase, which catalyzes the formation of 4-hydroxybenzoyl-CoA, is found in some bacteria and certain plant species.

The study of 4-hydroxybenzoyl-CoA has been motivated by its role in the degradation of environmental pollutants and its potential utility as a model for understanding other metabolic pathways. Further research is needed to fully elucidate its function in metabolism and its potential applications in biotechnology.