2Aadrenergic
The 2A adrenergic receptor, also known as ADRA2A, is a G protein-coupled receptor that belongs to the adrenergic receptor family. It is primarily activated by the neurotransmitters norepinephrine and epinephrine. These receptors are found throughout the central and peripheral nervous system, as well as in various tissues like platelets, adipose tissue, and the pancreas. When activated, the 2A adrenergic receptor typically inhibits adenylyl cyclase, leading to a decrease in intracellular cyclic AMP (cAMP) levels. This inhibitory effect plays a role in regulating neurotransmitter release, blood pressure, heart rate, and insulin secretion. The ADRA2A gene encodes the receptor protein. Variations in this gene have been associated with certain neurological and behavioral conditions, although research is ongoing. Medications that target 2A adrenergic receptors are used in the treatment of hypertension and glaucoma.