urokináz

Urokinase is a serine protease enzyme that plays a crucial role in the fibrinolytic system, which is responsible for breaking down blood clots. It is naturally produced by the kidneys and is also found in urine, hence its name. Urokinase acts by converting plasminogen, an inactive precursor, into plasmin, the active enzyme that degrades fibrin, the protein that forms the meshwork of blood clots.

Therapeutically, urokinase is used as a thrombolytic agent to dissolve blood clots in conditions such as deep vein thrombosis, pulmonary embolism, and myocardial infarction (heart attack). It is administered intravenously and works by activating the body's own clot-dissolving mechanisms. By breaking down clots, urokinase helps to restore blood flow to affected tissues and prevent further damage.

The use of urokinase requires careful medical supervision due to the risk of bleeding, a common side effect of thrombolytic therapy. Its effectiveness and safety profile have led to its widespread use in critical care settings. Research continues to explore its potential applications and optimize its therapeutic use.