serinylglycine

Serinylglycine is a dipeptide consisting of the amino acids serine and glycine linked by a peptide bond between the carboxyl group of serine and the amino group of glycine. It is sometimes written as Ser-Gly or serinylglycine, reflecting that serine is the N-terminal residue in the common naming convention.

Chemical and structural notes indicate a simple two-residue backbone with the molecular formula C5H10N2O4 and a nominal molecular weight around 162.15 g/mol. Serine provides the chiral center, while glycine is achiral, so the overall stereochemistry depends on the configuration of the serine residue (L- or D-). When glycine is the N-terminal residue, the dipeptide would be glycylserine.

Synthesis and occurrence: Serinylglycine can be synthesized by standard peptide coupling methods, for example using coupling reagents or solid-phase peptide synthesis to link serine to glycine. In biological and biochemical contexts, dipeptides can arise during proteolytic cleavage of proteins or appear as transient intermediates in peptide metabolism and experimental peptide hydrolysates.

Properties and uses: As a dipeptide with two amino and one carboxyl group, serinylglycine is expected to be highly soluble in water and moderately polar. It serves as a simple model compound in peptide chemistry and biochemistry for studying peptide transport, stability, or enzymatic interactions. It may also be used as a defined building block in the synthesis of longer peptides for research purposes.

Safety: There are no widely reported hazards specific to serinylglycine; like other amino acid dipeptides, it should be handled with standard laboratory safety practices.