retromerkomplex

The retromer complex is a multiprotein complex involved in the endocytosis and recycling of membrane proteins and lipids in eukaryotic cells. It is named for its role in retrograde transport, which is the movement of cargo from the endosome to the Golgi apparatus or the plasma membrane. The retromer complex is composed of three subunits: Vps26, Vps29, and Vps35. These subunits form a heterotetrameric complex that binds to cargo proteins and lipids, facilitating their transport back to the Golgi or plasma membrane. The retromer complex is essential for maintaining the proper function of these organelles and for the recycling of membrane proteins and lipids. Mutations in the genes encoding the retromer complex subunits have been linked to several human diseases, including Parkinson's disease and Charcot-Marie-Tooth disease. The retromer complex is a critical component of the endocytic pathway and plays a vital role in cellular homeostasis.