pyroglutamylhistidylproline
Pyroglutamylhistidine, often abbreviated as pGlu-His, is a dipeptide consisting of a pyroglutamate moiety linked to the amino terminus of histidine. Pyroglutamate refers to a cyclic lactam form of glutamine or glutamic acid that can form at the N-terminus of peptides. In pyroglutamylated peptides, the N-terminal residue is pyroglutamate, which can alter peptide stability, recognition by enzymes, and overall behavior in biological systems.
Chemical structure and properties: the dipeptide features a pyroglutamate unit connected by a peptide bond to
Formation and occurrence: pyroglutamyl peptides arise when N-terminal glutamine or glutamic acid residues cyclize to form
Analytical detection: identification and quantification of pGlu-His usually employ liquid chromatography coupled to tandem mass spectrometry
Significance: as with other pyroglutamyl peptides, pGlu-His can influence peptide stability, degradation pathways, and interactions with