dimethylglycine

Dimethylglycine, commonly abbreviated DMG, is a derivative of the amino acid glycine in which the amino nitrogen bears two methyl groups, giving the name N,N-dimethylglycine. Its chemical formula is C4H9NO2. DMG is a naturally occurring compound found in trace amounts in some foods and is also produced endogenously in small quantities. It is not considered an essential nutrient for humans.

DMG is marketed as a dietary supplement and has been promoted for immune support, fatigue reduction, and improved athletic performance. The clinical evidence for these uses is limited and inconsistent. Some small or preliminary studies have suggested potential immune-modulating effects or modest improvements in exercise tolerance, but larger, well-designed trials have not established clear or consistent benefits.

In terms of metabolism, DMG is thought to participate in methylation-related pathways, but precise in vivo roles in humans remain unclear. It is generally regarded as well tolerated when taken at common supplement doses, with rare reports of mild adverse effects such as digestive upset or headaches. Long-term safety data and potential interactions with medications are not well defined, so individuals with health conditions or those who are pregnant or nursing should consult a healthcare provider before use.

Regulatory status varies by country. In many places, DMG is sold as a dietary supplement rather than a prescription drug, and it has not been approved as a treatment for any medical condition by major regulatory agencies.