cdc45MCMGINS
CDC45MCMGINS is a protein complex involved in DNA replication in eukaryotic cells. It is a crucial component of the pre-replication complex (pre-RC), which is assembled on the DNA during the G1 phase of the cell cycle and is essential for initiating DNA replication. The complex itself is composed of three subunits: CDC45, MCM2-7 (a heterohexameric ring-like structure), and GINS (a tetrameric protein complex). Together, these proteins form the core of the replication machinery.
The formation of the CDC45MCMGINS complex is a tightly regulated process. CDC45 is recruited to the origin
The precise mechanism by which CDC45MCMGINS activates the MCM helicase is still an area of active research.