bradykinin1

Bradykinin1 (BK1) is a G protein-coupled receptor that plays a crucial role in the renin-angiotensin-aldosterone system (RAAS) and the kallikrein-kinin system (KKS). It is primarily expressed in the kidneys, where it is involved in the regulation of blood pressure and fluid balance. BK1 is activated by bradykinin, a peptide hormone that is released in response to tissue injury or inflammation.

The activation of BK1 leads to the opening of chloride channels, resulting in an increase in intracellular chloride concentration and a subsequent increase in cell volume. This process is known as cell swelling and is a key mechanism in the regulation of blood pressure and fluid homeostasis. BK1 is also involved in the regulation of renal blood flow and glomerular filtration rate.

In addition to its physiological roles, BK1 has been implicated in various pathological conditions, including hypertension, heart failure, and kidney disease. It has been suggested that targeting BK1 could be a potential therapeutic strategy for these conditions. However, further research is needed to fully understand the complex roles of BK1 and to develop effective therapeutic interventions.

The BK1 receptor is a member of the bradykinin receptor family, which also includes BK2 and BK3 receptors. Each of these receptors has a unique distribution and function, and they play distinct roles in the body's response to bradykinin. BK1 is the most abundant bradykinin receptor in the kidneys, while BK2 is primarily expressed in the heart and BK3 is found in various tissues, including the brain and lungs.