Myeloperoksidaasin

Myeloperoxidase is an enzyme produced by granulocytes, a type of white blood cell. Its primary role is in the innate immune system, specifically in the defense against microbial infections. When a pathogen is detected, granulocytes release myeloperoxidase into the phagosome, the compartment where the pathogen is engulfed. Within the phagosome, myeloperoxidase utilizes hydrogen peroxide and chloride ions to produce hypochlorous acid, a potent antimicrobial agent. Hypochlorous acid is highly reactive and effectively kills bacteria, fungi, and viruses.

Myeloperoxidase is abundant in neutrophils, which are the most common type of granulocyte. The enzyme contributes to the characteristic green color of pus, which is a visible sign of infection and inflammation. Elevated levels of myeloperoxidase in the blood can be indicative of inflammatory conditions or certain types of leukemia. While its role in host defense is crucial, myeloperoxidase can also contribute to tissue damage during prolonged or excessive inflammation. Research into myeloperoxidase is ongoing, exploring its potential as a biomarker for disease and its involvement in various pathological processes.