HPMC

Hydroxypropyl methylcellulose (HPMC) is a cellulose ether produced by partially replacing hydroxyl groups on cellulose with methoxy and hydroxypropyl groups. It appears as a white, odorless powder and is non-ionic. In water, HPMC forms viscous solutions; the viscosity depends on molecular weight and substitution pattern and is available in a broad range of grades and particle sizes. HPMC is soluble in cold water and can form gels or films depending on the grade and conditions, making it versatile for processing.

HPMC is widely used as a polymeric excipient in pharmaceutical, food, and cosmetic applications. In pharmaceuticals, it serves as a binder and filler in solid dosage forms, a thickener and stabilizer in liquids, and a film-forming coating for tablets and controlled-release matrices. It also functions as a matrix-forming polymer for sustained-release formulations and as a thickener in topical and ophthalmic products. In cosmetics, HPMC acts as a thickener, texture enhancer, and film-forming agent in creams, gels, and lotions. In the food industry, it is used as a thickener and stabilizer, and in some cases as a vegan, gluten-free binder.

HPMC is valued for its chemical stability across a wide pH range, thermal processing tolerance, and compatibility with a variety of active ingredients. It is generally regarded as safe for its intended uses and is supplied in pharmacopeial grades (such as USP/NF, EP) and food-grade forms, with selection depending on desired viscosity and release characteristics. Proper storage—dry, sealed conditions—helps maintain its quality.